Journal
SYNTHETIC COMMUNICATIONS
Volume 37, Issue 22-24, Pages 4253-4263Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701575665
Keywords
antibiotics; antitumor; epoxide; natural products; total synthesis
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Short and efficient synthesis of rubrolide E from commercially available 4-methoxyacetophenone, employing ring-closing metathesis, Knoevenagel condensation, and Reformatsky reactions, are the key steps are described.
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