Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 2, Issue 2, Pages 306-313Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200600322
Keywords
amination; benzamide; catalysis; palladium; phosphines
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Easily accessible benzamide-derived hemilabile phosphine ligands were efficiently prepared through ortho-directed lithiation of the corresponding NN-diethylbenzamide followed by quenching with chlorodialkylphosphines. These structurally simple hemilabile ligands were found to be highly effective in palladium-catalyzed amination of aryl and heteroaryl chlorides. Various sterically congested and functionalized aryl halide substrates were compatible in these reaction conditions. By using optimized reaction conditions, remarkable catalyst productivity (total turnover number up to 8400) was obtained.
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