Journal
NEURON
Volume 53, Issue 1, Pages 103-115Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2006.11.021
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Funding
- NIMH NIH HHS [F31 MH073311-02, R01 MH069883, MH073311, MH09883, F31 MH073311] Funding Source: Medline
- NINDS NIH HHS [NS007366, T32 NS007366] Funding Source: Medline
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Drosophila mushroom bodies (MB) are bilaterally symmetric multilobed brain structures required for olfactory memory. Previous studies suggested that neurotransmission from MB neurons is only required for memory retrieval. Our unexpected observation that Dorsal Paired Medial (DPM) neurons, which project only to MB neurons, are required during memory storage but not during acquisition or retrieval, led us to revisit the role of MB neurons in memory processing. We show that neurotransmission from the alpha'beta' subset of MB neurons is required to acquire and stabilize aversive and appetitive odor memory, but is dispensable during memory retrieval. In contrast, neurotransmission from MB alpha beta neurons is only required for memory retrieval. These data suggest a dynamic requirement for the different subsets of MB, neurons in memory and are consistent with the notion that recurrent activity in an MB alpha'beta' neuron-DPM neuron loop is required to stabilize memories formed in the MB alpha beta neurons.
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