Journal
JOURNAL OF PROTEOME RESEARCH
Volume 6, Issue 1, Pages 89-96Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr060149v
Keywords
intra-amniotic infection; preterm birth; cervical-vaginal fluid
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Funding
- NIAID NIH HHS [R01 AI042490-06, AI42490, R01 AI042490-07, R01 AI042490] Funding Source: Medline
- NICHD NIH HHS [R01 HD006159, HD06159] Funding Source: Medline
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Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimensional protein identification technology (LC/LC-MS/MS) and MALDI-TOF-MS analyses. Analyses of CVF proteome identified 205 unique proteins and differential expression of 27 proteins in controls and IAI samples. Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI.
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