Journal
CANCER LETTERS
Volume 245, Issue 1-2, Pages 61-68Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.12.026
Keywords
XPD; single nucleotide polymorphism; smoking; pancreatic cancer
Categories
Funding
- NCI NIH HHS [R01 CA098380, R03 CA084581, P30 CA016672, CA16672, CA98380] Funding Source: Medline
- NIEHS NIH HHS [P30 ES07784, P30 ES007784] Funding Source: Medline
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We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn 312 Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction =0.03). The (312)ASP-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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