Journal
FEBS LETTERS
Volume 581, Issue 1, Pages 45-51Publisher
WILEY
DOI: 10.1016/j.febslet.2006.11.075
Keywords
MARCH-IX; ICAM-1; E3 ubiquitin ligase; RING-CH; RING E3 ligase; transmembrane E3 ligase
Funding
- Medical Research Council [G0600823(78905), G9800943, G0600823] Funding Source: Medline
- Wellcome Trust [084957] Funding Source: Medline
- Medical Research Council [G9800943] Funding Source: researchfish
- MRC [G9800943] Funding Source: UKRI
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The membrane associated RING-CH (MARCH) family of genes encode a novel group of RING-type ubiquitin E3 ligases. Overexpression of one of these family members, MARCH-IX, leads to a downregulation of cell surface major histocompatibility complex (MHC) class I and CD4. Here, we identify MARCH-IX as the first ubiquitin E3 ligase to control expression of the critical cell adhesion molecule ICAM-1. MARCH-IX expression causes ubiquitination and downregulation of ICAM-1 and a short alternative transcript of MARCH-IX lacking the RING-CH domain, termed MARCH-IX RINGless, is shown to act as a positive regulator of MARCH-IX activity. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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