Journal
SCIENCE
Volume 315, Issue 5809, Pages 207-212Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1132894
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Funding
- Medical Research Council [G0000508, G9722968] Funding Source: researchfish
- Medical Research Council [G9722968, G9722968(65078), G0000508, G0000508(56841)] Funding Source: Medline
- NIAID NIH HHS [UO1 AI50913-01, U01 AI050913-02, U01 AI050913, U01 AI050913-01A1] Funding Source: Medline
- NLM NIH HHS [R01 LM007938, R01 LM007938-04, R01 LM006845, R01 LM006845-08] Funding Source: Medline
- Wellcome Trust [072031] Funding Source: Medline
- MRC [G9722968, G0000508] Funding Source: UKRI
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We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the similar to 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
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