Journal
NEUROIMAGE
Volume 34, Issue 2, Pages 733-742Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2006.09.020
Keywords
diffusion tensor imaging; fractional anisotropy; apparent diffusion coefficient; reproducibility; hemispheric differences; brain maturation; children
Funding
- NCRR NIH HHS [M01 RR 00052, M01 RR000052] Funding Source: Medline
- NINDS NIH HHS [R01 NS042851, 5R01 NS042851] Funding Source: Medline
Ask authors/readers for more resources
We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5-19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal). Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation <= 2.7%) and inter-rater (coefficients of variation <= 4.8%) reproducibility. For between-scan reproducibility, the coefficients of variation were <= 5.0%. Mean asymmetry indices were in the range from -4% to 9% for FA and from -6% to 3% for ADC. ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts. Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population. (c) 2006 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available