Journal
MOVEMENT DISORDERS
Volume 22, Issue 2, Pages 155-161Publisher
WILEY
DOI: 10.1002/mds.21236
Keywords
pre-Botzinger complex; arcuate nucleus; multiple system atrophy; apnea, stridor
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Funding
- NINDS NIH HHS [P01 NS32352-P2] Funding Source: Medline
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Multiple system atrophy may manifest with severe respiratory disorders, including sleep apnea and laryngeal stridor, which reflect a failure of automatic control of respiration. This function depends on a pontomedullary network of interconnected neurons located in the parabrachial/Kolliker Fuse nucleus in the pons, nucleus of the solitary tract, and ventrolateral medulla. Neurons in the preBotzinger complex expressing neurokinin-1 receptors are critically involved in respiratory rhythmogenesis, whereas serotonergic neurons in the medullary raphe and glutamatergic neurons located close to the ventral medullary surface are involved in central chemosensitivity to hypercapnia, hypoxia, or both. Pathological studies using selective neurochemical markers indicate that these neuronal groups are affected in multiple system atrophy. This finding may provide potential anatomical substrates for the respiratory manifestations of the disease. (C) 2006 Movement Disorder Society.
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