Journal
BIOINFORMATICS
Volume 23, Issue 2, Pages 252-254Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btl574
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The scale of genetic-variation datasets has increased enormously and the linkage equilibrium (LD) structure of these polymorphisms, particularly in whole-genome association studies, is of great interest. The significant computational complexity of calculating single- and multiple-marker correlations at a genome-wide scale remains challenging. We have developed a program that efficiently characterizes whole-genome LD structure on large number of SNPs in terms of single- and multiple-marker correlations.
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