Journal
BRITISH JOURNAL OF CANCER
Volume 96, Issue 1, Pages 6-10Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603519
Keywords
stem cell; ependymoma; brain; tumour; CD133 radial glia
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Funding
- NCI NIH HHS [U01 CA081457, CA096832, P01 CA096832, CA081457, UM1 CA081457] Funding Source: Medline
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Ependymomas are tumours that arise throughout the central nervous system. Little is known regarding the aberrant cellular and molecular processes that generate these tumours. This lack of knowledge has hampered efforts to reduce the significant mortality and morbidity that are associated with ependymoma. Here, we review recent data that suggest that radial glia are cells of origin of ependymoma, and discuss the processes that might transform these neural progenitors into ependymoma cancer stem cells.
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