Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 2, Pages 1138-1145Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.10.005
Keywords
IPTMP; 5-aminoisophthalate tetramethylene phosphonic acid; chelating agent; Tc-99m; bone seeking agent
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The tetraphosphonate ligand, 5-amino-1,3-bis(ethylamine-(NN-dimethyl diphosphonic acid) acetamido) benzene (IPTMP) used in the present study was prepared from 5-nitroisophthalate dimethylester to label with radionuclide for targeted diagnosis and therapy. The synthesized multidentate phosphonate ligand was characterized on the basis of spectroscopic techniques, which exhibited good metal ion control properties when complexed to 99mTe with high in vitro and in vivo stability. Excellent quality bone images of rabbit were imaged showing rapid clearance of background activity and visualization of skeleton at 1h. (c) 2006 Elsevier Ltd. All rights reserved.
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