Journal
BRITISH JOURNAL OF CANCER
Volume 96, Issue 1, Pages 11-15Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603535
Keywords
BRCA1; BRCA2; penetrance; breast cancer; ovarian cancer
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BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.
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