Journal
BRITISH JOURNAL OF CANCER
Volume 96, Issue 1, Pages 1-5Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603518
Keywords
cadherin; cancer; cytoskeleton; EMT; invasion; podoplanin
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Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.
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