Journal
ORGANIC LETTERS
Volume 9, Issue 2, Pages 227-230Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol062656o
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Funding
- NCI NIH HHS [R01 CA090349-07, CA-95741, R01 CA090349, R01 CA090349-06A1, P01 CA095471, CA-90349, R01 CA090349-08] Funding Source: Medline
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In this letter we describe an efficient synthesis of psympederin, a hybrid between the novel antitumor natural product psymberin and the blister beetle toxin pederin. Evaluation of antiproliferative activity reveals that the dihydroisocoumarin fragment is important for psymberin toxicity and the cyclic pederate fragment is important for pederin/mycalamide toxicity. On the basis of preliminary results described herein, we speculate that, despite their structural resemblance, psymberin and pederin/mycalamide induce toxicity through different mechanisms.
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