4.7 Article

Synthesis of the isonicotinoylnicotinamide scaffolds of the naturally occurring isoniazid-NAD(P) adducts

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 2, Pages 675-678

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo062100e

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The first syntheses of the 1-hydroxy-1-(pyridin-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one heterocycle and the 3-aminocarbonyl-4-isonicotinoyl-1,4-dihydropyridine framework present in the isoniazid-NAD(P) adducts are described.

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