Journal
TETRAHEDRON
Volume 63, Issue 4, Pages 898-903Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.11.036
Keywords
difluoromethylene; difluoromethylene-containing alcohol; aldehyde; potassium tert-butoxide
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A new fluorine-containing synthon, (RCOCF2SO2R2)-C-1 (2, R-1, R-2=morpholino, piperidino, etc.), was developed for the introduction of difluoromethylene sulfonamide or difluoromethylene group. Under different conditions, 2 reacted readily with aromatic aldehydes to give the corresponding difluoromethylene-containing alcohols or diols in moderate to good yields in the presence of potassium tert-butoxide. Difluoromethylene sulfonamide group was introduced into organic compounds directly for the first time by this method. (c) 2006 Elsevier Ltd. All rights reserved.
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