Journal
POLYHEDRON
Volume 26, Issue 2, Pages 434-447Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2006.06.036
Keywords
gold complexes; metallacylic complexes; crystal structures; electrospray mass spectrometry; anti-tumour activity
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Reactions of cycloaurated gold(III) dichloride complexes, with 1,2-C6H4(NHCOMe)(2) and silver(I) oxide, or with C2H4(NHSO(2)Tol)(2) (Tol = p-tolyl) or 1,2-C6H4(NHSO(2)Tol)(2) and trimethylamine, give a series of new auracyclic complexes containing the Au-NR-CH2,CH2-NR (R = SO(2)Tol) and Au-NR-C6H4 NR (R = COMe or SO(2)Tol) five-membered ring systems. An X-ray structure determination on (2-bp)Au{N(COMe)C6H4N(COMe)}(2-bp = cycloaurated 2-benzylpyridine) shows the presence of puckered metallacyclic rings, with both acetyl substituents positioned below the Au(III) coordination plane. The complex (2-bp)Au{N(COMe)C6H4N(COMe)} undergoes ring cleavage in the presence of halide and water, to give the complex (2-bp)Au{N(COMe)C6H4NH(COMe)}Cl, which was characterised crystallographically, and shown to contain a monodentate amidate ligand. Biological activity studies of the new auracyclic complexes are also reported, against P388 murine leukaemia cells and a range of bacteria and fungi, with a number of complexes showing high activity. (c) 2006 Elsevier Ltd. All rights reserved.
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