Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 204, Issue 1, Pages 153-160Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20061918
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCRR NIH HHS [P20 RR015577, P20RR15577-02, P20 RR018758, P20RR018758-01] Funding Source: Medline
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The discovery of lymphocytes bearing two light chains in mice carrying self-reactive antibody transgenes has challenged the one lymphocyte-one antibody rule. However, the extent and nature of allelically included cells in normal mice is unknown. We show that 10% of mature B cells coexpress both Ig kappa alleles. These cells are not the result of failure in allelic exclusion per se, but arise through receptor editing. We find that under physiological conditions, editing occurs both by deletion and by inclusion with equal probability. In addition, we demonstrate that B lymphocytes carrying two B-cell receptors are recruited to germinal center reactions, and thus fully participate in humoral immune responses. Our data measure the scope of allelic inclusion and provide a mechanism whereby autoreactive B cells might escape central tolerance.
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