Journal
VACCINE
Volume 25, Issue 7, Pages 1175-1182Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.10.022
Keywords
meningococcal C; conjugate vaccine; room temperatures stability
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Millions of vaccine doses are wasted each year due to a lapse in recommended storage conditions. Maintaining the cold chain for vaccines is both expensive and difficult, especially in developing countries. The present study investigated the safety and immunogenicity of a single dose of the conjugated meningococcal Group C vaccine, Menjugate (R) stored for 6 months at room temperature (25 +/- 2 degrees C, N = 250) or at 2-8 degrees C (N = 250) when administered to 12-23 months toddlers. In the two respective groups, 87 and 88% of toddlers reached bactericidal antibodies titers of at least 1:8. The immunogenicity of Menjugate (R) stored at room temperature was not inferior to that stored at 2-8 degrees C. The safety profile and immunogenicity of the vaccine was not influenced by the storage condition. (c) 2006 Elsevier Ltd. All rights reserved.
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