Journal
POLYMER
Volume 48, Issue 3, Pages 799-804Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2006.12.015
Keywords
chlorpheniramine maleate; water-soluble polymers; pi-pi interactions
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The interaction of the pharmacologically important chlorpheniramine maleate (CPM) with polyanions containing sulfonate groups such as poly(sodium 4-styrenesulfonate) (PSS), poly(sodium vinylsulfonate) (PVS), and the more hydrophobic poly(sodium 2-(N-acrylamido)-2-methyl-propanesulfonate) (PAMPS) has been studied by H-1 NMR. It was found that the pK(a) of the low-molecular weight molecule (LMWM) may be modified by its interaction with the polyanions, changing from 3 to 5, due to electric charge compensation. Interestingly, the interaction of CPM with PSS produces changes in CPM resonances, such as a general broadening and upfield shifts of the signals, and NOE effects between the LMWM and the water-soluble polymer (WSP) that indicate the presence of pi-pi interactions. (c) 2006 Elsevier Ltd. All rights reserved.
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