Journal
TETRAHEDRON LETTERS
Volume 48, Issue 5, Pages 799-803Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.11.160
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An efficient chernoenzymatic synthesis of UDP-N-acetylmuramyl-L-alanyl-'Y-D-glutamyt-meso-diaminopimelyl-D-alanylD-alanine (Park's nucleotide) is reported. UDP-MurNAc is efficiently synthesized by a minimum number of protecting strategies. One-pot amino acid ligation reactions catalyzed by MurC, D, E, and F enzymes are amenable to scale-up production. (c) 2006 Published by Elsevier Ltd.
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