Journal
TETRAHEDRON
Volume 63, Issue 5, Pages 1146-1153Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.11.055
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Coupling reactions of alpha-chloroesters with aryl halides (alpha-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or beta-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups. (c) 2006 Elsevier Ltd. All rights reserved.
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