Journal
NEUROSCIENCE LETTERS
Volume 412, Issue 2, Pages 95-100Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.10.040
Keywords
glutamate; synaptic transmission; veratridine; potassium
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Funding
- Wellcome Trust [017948] Funding Source: Medline
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Accumulation of neurotransmitter into synaptic vesicles is powered by the vacuolar proton ATPase. We show here that, in brain slices, application of the H(+)-ATPase inhibitors bafilomycin or concanamycin does not efficiently deplete glutamatergic vesicles of transmitter unless vesicle turnover is increased. Simulations of vesicle energetics suggest either that bafilomycin and concanamycin act on the H(+)-ATPase from inside the vesicle, or that the vesicle membrane potential is maintained after the H'-ATPase is inhibited. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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