Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 131, Issue 1-2, Pages 65-69Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2006.07.004
Keywords
nitric oxide; conscious rats; RVLM; arterial pressure
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We evaluated the cardiovascular effects of nitric oxide (NO) inhibitors microinjected into the rostral ventrolateral medulla (RVLM) of conscious rats. Application of L-NAME or ammoguanidine (AG) induced an increase in arterial blood pressure (MAP) and an increase in heart rate, whereas 7-nitroindazole (7-NI) decreased MAP and HR. Microinjection of glutamate produced an increase in MAP which was followed by either a tachycardia or a bradycardia. Such responses were blocked totally by prior administration of L-NAME and attenuated (similar to 50%) by 7-NI. In contrast, glutamate responses were enhanced by following AG. We conclude that in conscious rats, NO has tonic effects in the RVLM and may participate in the modulation of the actions of glutamate through iNOS and nNOS pathways. (c) 2006 Elsevier B.V. All rights reserved.
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