Journal
ANALYTICA CHIMICA ACTA
Volume 583, Issue 1, Pages 190-196Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2006.09.042
Keywords
ion-selective electrodes; selectivity enhancement; clinical analysis; anion detection; solvent polymeric membrane
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Funding
- NIGMS NIH HHS [GM07178, R01 GM071623-03] Funding Source: Medline
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A large and robust selectivity improvement of ion-selective electrodes is presented for the measurement of abundant ions. An improvement in selectivity by more than two orders of magnitude has been attained for the hydrophilic chloride ions measured in a dilute background of the lipophilic ions perchlorate and salicylate in a pulsed chronopotentiometric measurement mode. This is attributed to a robust kinetic discrimination of the dilute lipophilic ions in this measuring mode, which is not possible to achieve in classical potentiometry. Maximum tolerable concentrations of the interfering ions are found to be on the order of 30 mu M before causing substantial changes in potential. As an example of practical relevance, the robust detection of chloride in 72 mu M salicylate (reflecting 1: 10 diluted blood) with a detection limit of 0.5 mM chloride is demonstrated. Corresponding potentiometric sensors did not give a useful chloride response under these conditions. (c) 2006 Elsevier B.V. All rights reserved.
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