Journal
GENETICS
Volume 175, Issue 2, Pages 963-967Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.106.067850
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Funding
- NCI NIH HHS [CA77325, R01 CA077325] Funding Source: Medline
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The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1(+), a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G(1) phase of the cell cycle. Xlf1 is the ortholog of budding yeast Nej1 and human XLF/Cernunnos proteins.
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