Journal
BULLETIN OF MATHEMATICAL BIOLOGY
Volume 69, Issue 2, Pages 483-494Publisher
SPRINGER
DOI: 10.1007/s11538-006-9114-8
Keywords
signaling networks; network motifs; cellular differentiation; bHLH dimerization; competitive heterodimerization; inhibitors of differentiation (Id)
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High-dimensional switches have been proposed as a way to model cellular differentiation, particularly in the context of basic Helix-Loop-Helix (bHLH) competitive heterodimerization networks. A previous study derived a simple rule showing how many elements can be co-expressed, depending on the rate of competition within the network. A limitation to that rule, however, is that many biochemical parameters were considered to be identical. Here, we derive a generalized rule. This in turns allows one to study more ways in which these networks could be regulated, linking intrinsic cellular differentiation determinants to extra-cellular cues.
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