Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 74, Issue 2, Pages 282-289Publisher
SPRINGER
DOI: 10.1007/s00253-006-0763-1
Keywords
thymine; biosynthesis; flavin; thymidylate synthase
Categories
Funding
- NIGMS NIH HHS [R01 GM65368-01] Funding Source: Medline
Ask authors/readers for more resources
The two long- known classical enzymes of uridyl-5-methylation, thymidylate synthase and ribothymidyl synthase, have been joined by two alternative methylation enzymes, flavin-dependent thymidylate synthase and folate-dependent ribothymidyl synthase. These two newly discovered enzymes have much in common: both contain flavin cofactors, utilize methylenetetrahydrofolate as a source of methyl group, and perform thymidylate synthesis via chemical pathways distinct from those of their classic counterparts. Several severe human pathogens (e.g., typhus, anthrax, tuberculosis, and more) depend on these alternative enzymes for reproduction. These and other distinctive properties make the alternative enzymes and their corresponding genes appealing targets for new antibiotics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available