Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 27, Issue 1, Pages 45-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2006.11.007
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Funding
- NHLBI NIH HHS [1R01 HL 071163, N01 HV 28184] Funding Source: Medline
- NIAID NIH HHS [1P01 AI 062885, P01 AI062885] Funding Source: Medline
- NIEHS NIH HHS [P30 ES006676] Funding Source: Medline
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This article provides an overview of NADPH oxidase and its role in allergic inflammation. A background and historical perspectives of NADPH oxidase are first provided, followed by a detailed overview of mammalian NADPH oxidase subunits and their functional organization. Plant NADPH oxidase, the authors' discovery of NADPH oxidase in pollens, and their contribution to allergic inflammation are then discussed, concluding with a discussion of future directions and outstanding questions that require attention.
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