Journal
JOURNAL OF BACTERIOLOGY
Volume 189, Issue 3, Pages 1163-1170Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01343-06
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Funding
- NIGMS NIH HHS [R01 GM058213, GM58213, F32 GM072393, GM072393] Funding Source: Medline
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Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains belonging to the nonpathogenic species Bacillus subtilis. Our M-CGH results indicate that there is considerable genetic heterogeneity among members of this species; nearly one-third of Bsu168-specific genes exhibited variability, as measured by the microarray hybridization intensities. The variable loci include those encoding proteins involved in antibiotic production, cell wall synthesis, sporulation, and germination. The diversity in these genes may reflect this organism's ability to survive in diverse natural settings.
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