Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 57, Issue 2, Pages 396-404Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21150
Keywords
fMRI; echo-planar imaging; susceptibility artifact; z-shim compensation; orbitofrontal cortex
Funding
- NIDA NIH HHS [5 R37 DA09842, R37 DA009842, R01 DA009842] Funding Source: Medline
- NIMH NIH HHS [R01 MH070037, 5 P50 MH068582, 5 R01 MH38321] Funding Source: Medline
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Susceptibility-induced magnetic field gradients (SFGs) can result in severe signal loss in the orbitofrontal cortex (OFC) in gradient-echo-based functional MRI (fMRI) studies. Although conventional z-shim techniques can effectively recover the MRI signal in this region, the substantial penalty in imaging time hampers their use in routine fMRI studies. A modified z-shim technique with high imaging efficiency is presented in this study. In this technique, z-shim compensations are applied only to a selective volume where the susceptibility artifact is severe. The results of an fMRI study (N = 6) demonstrate the feasibility of detecting the OFC activation with z-shim in whole-brain fMRI studies at a temporal resolution of 2 s.
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