Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 182, Issue 2, Pages 333-348Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426500600919207
Keywords
synthetic chemistry; 2-quinazolines; 1,3,4-oxadiazoles; 1,3,4-thiadiazoles; condensations; antimicrobial agent
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A new series of substituted 2-mercapto-3-(4-chlorophenyl)-6-iodo-3H-quinazolin-4-ones was prepared and screened for antimicrobial activity. Compounds 11, 13, 17, and 18 showed a remarkably broad spectrum of antimicrobial activity and could be useful as templates for further development through modification or derivatization to design more potent antimicrobial agents, A detailed synthesis of new 2-mercaptoquinazolinones and their antimicrobial screening are reported.
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