Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 18, Issue 1-2, Pages 143-157Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2007.01.017
Keywords
liver; cytokines; hepatitis; Kupffer cells; tolerogenic responses
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From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations. (c) 2007 Elsevier Ltd. All rights reserved.
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