Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 306, Issue 1, Pages 161-165Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2006.10.021
Keywords
phenothiazine drug; promethazine hydrochloride; cloud point; Hofmeister series; mixed micelles
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We have studied the clouding phenomena in promethazine hydrochloride (PM) aqueous solutions in presence of electrolytes and non-electrolytes. PMT, a tranquillizer, shows phase separation. The cloud point (CP) decreases with increase in pH due to deprotonation of drug molecules. At constant pH, increasing salt addition causes an increase in CP, which is explained on the basis of their position in Hofmeister series and their hydrated radii. With quaternary salts CP increases due to adsorption/mixed micelle formation. Ureas decrease the CP and the behavior is explained on the basis of removal of water from the headgroup region. (c) 2006 Published by Elsevier Inc.
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