Journal
INFECTION AND IMMUNITY
Volume 75, Issue 2, Pages 1059-1062Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.01400-06
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Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
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