Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 260, Issue 2-3, Pages 166-176Publisher
ELSEVIER
DOI: 10.1016/j.ijms.2006.09.019
Keywords
imaging MS; MALDL intermediate pressure; linear ion trap; phospholipids
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We describe a new intermediate-pressure MALDI linear ion trap mass spectrometer and its capabilities for imaging mass spectrometry. The instrument design is described and is characterized in terms of four performance issues (1) MALDI performance at intermediate pressure; (2) analysis of samples on non-conductive and conductive glass slides; (3) critical importance of tandem mass spectrometry (both MS2 and MS3) for identification of analyte species and imaging of isobaric species; (4) capability for repeated analysis of the same tissue section. Application of the new instrument to imaging phospholipids in rat brain sections is described in detail. (C) 2006 Elsevier B.V. All rights reserved.
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