Journal
CONTRACEPTION
Volume 75, Issue 2, Pages 142-151Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.contraception.2006.08.014
Keywords
vaginal gel; contraceptive agents; microbicide; fluorimeter; epithelial coating
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Funding
- NIAID NIH HHS [P30 AI064518, R01 AI048103, AI48103] Funding Source: Medline
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Objective: We used a new optical imaging technique to compare human intravaginal coating distributions of Conceptrol (R) (Advanced Care Products, Brunswick, NJ) and Advantage (TM) (Columbia Laboratories, Aventuna, FL). These gels are surrogates for future microbicidal gels, differing in molecular structures and biophysical properties. Methods: For each protocol, a 3-mL gel bolus was inserted to the posterior fornix while the woman was in the supine position. She then either (1) remained supine (10 min); or (2) sat up (I min), stood up (I min), sat down (I min) and returned to supine for a net elapsed time of 10 min. The imaging device is sized/shaped like a phallus, and measurements while the device was inserted provide data that simulate periintromission coating. Results: Coating by Advantage (TM) was more extensive and uniform than coating by Conceptrols, with smaller bare spots of uncoated epithelium. Change in posture tended to increase extent and uniformity of coating, details differing between gels. Conclusions: Results are consistent with predictions of mechanistic coating theory, using gel theological data as inputs. (c) 2007 Elsevier Inc. All rights reserved.
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