Journal
STROKE
Volume 38, Issue 2, Pages 759-762Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.STR.0000247868.97078.10
Keywords
brain edema; cerebral hemorrhage; iron; thrombin
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Funding
- NINDS NIH HHS [NS-47245, NS-39866, NS-17760] Funding Source: Medline
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Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury. (Stroke. 2007;38[part 2]:759-762.)
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