Journal
JOURNAL OF CELL SCIENCE
Volume 120, Issue 3, Pages 385-393Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.03363
Keywords
Wnt; LEF; TCF; signalling; beta-catenin; tissue-specificity; vertebrates; embryonic development; stem cells; alternative splicing
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Funding
- Wellcome Trust Funding Source: Medline
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The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.
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