Journal
IMMUNOLOGICAL REVIEWS
Volume 215, Issue -, Pages 114-122Publisher
WILEY
DOI: 10.1111/j.1600-065X.2006.00483.x
Keywords
gamma delta T cells; homeostasis; tissue repair; skin
Categories
Funding
- NIAID NIH HHS [AI61685, AI52257, AI36963] Funding Source: Medline
- NIDDK NIH HHS [DK073098] Funding Source: Medline
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There is a resident population of T cells found in murine skin that expresses an invariant V gamma 3V delta 1 T-cell receptor (TCR), and these cells are significantly different from lymphoid gamma delta T cells and alpha beta T cells in terms of ontogeny, tissue tropism, and antigen receptor diversity. These dendritic epidermal T cells are derived from fetal thymic precursor cells, are in constant contact with neighboring epidermal cells, and express a monoclonal gamma delta TCR only found in the skin. Skin gamma delta T cells have been shown to play unique roles in tissue homeostasis and during tissue repair through local secretion of distinct growth factors including keratinocyte growth factors and insulin-like growth factor-1. In this review, we discuss evidence supporting a role for cross talk between skin gamma delta T cells and keratinocytes that contributes to the maintenance of normal skin and wound healing.
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