Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 183, Issue 1-2, Pages 33-42Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2006.11.005
Keywords
follicle-associated epithelium; ileum; oral immunization; permeability; Peyer's patches; psychological stress
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Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines. (c) 2006 Elsevier B.V. All rights reserved.
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