Journal
CURRENT ORGANIC CHEMISTRY
Volume 11, Issue 3, Pages 267-283Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138527207779940874
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Highly toxic organophosphorus inhibitors of acetylcholinesterase referred as nerve agents are considered to be among the most dangerous chemical warfare agents. The oximes represent very important part of antidotal medical countermeasures. They are used to reactivate the nerve agent-inhibited acetylcholincsterase. Despite long-term research activities, there is no single. broad-spectrum oxime suitable for the antidotal treatment of poisoning with all organo-phosphorus agents. Therefore, the development of new structural analogues Of currently available oximes should continue to increase the effectiveness of antidotal treatment of poisoning by organophosphorus compounds. The review describes the development of new structural analogues of currently available oximes and the evaluation of their potency to counteract the acute toxicity of some nerve agents (tabun, cyclosarin) in comparison with commonly used oximes (pralidoxime, obidoximw, trimedoximc, III-6).
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