Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 183, Issue 1-2, Pages 43-49Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2006.11.003
Keywords
Leishmania major; hyperalgesia; interleukins; pain tests; immunoassays
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infection with a high dose of Leishmania major has been shown to induce hyperalgesia in BALB/c mice accompanied by a sustained upregulation of Interleukin-1 beta (IL-1 beta) and an early upregulation of Interleukin-6 (IL-6). On the other hand, Interleukin 10 (IL-10) has been demonstrated to be hypoalgesic in other models such as rats exposed to UV rays. In this study, we injected BALB/c mice with a high dose of Leishmania major and treated them with IL-10 (15 ng/animal) for six consecutive days. Hyperalgesia was assessed using thermal pain tests and the levels of IL-I beta and IL-6 were also assessed at different post-infection days. Our results show that IL-10 can reduce the Leishmania major induced hyperalgesia during the treatment period through a direct effect on the levels of IL-1 beta which seems to play an important role in this hyperalgesia induction since its level was reduced during the period of IL-10 injection and was increased again when this treatment was stopped. On the contrary IL-10 has no direct effect on the levels IL-6 which seems to have no direct role in the induced hyperalgesia. (c) 2006 Elsevier B.V All rights reserved.
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