Fetal and maternal vascular lesions

Many commonly diagnosed disorders of the placenta relate to maternal and fetal blood flow and are thus common in the placentas of infants with adverse perinatal outcomes. Severe uteroplacental vascular disease may lead to extensive placental infarction and villous changes of reduced uteroplacental blood flow, a morphologic feature commonly associated with intrauterine growth restriction and fetal demise. Lesser degrees of villous change are seen in many infants with premature delivery, term, and multiple births resulting in admission to the neonatal intensive care units. Fetal vascular lesions including chorangiosis and fetal thrombotic vasculopathy are two processes that appear to be associated with increased risk of poor outcome. (C) 2007 Elsevier Inc. All rights reserved.