Journal
MITOCHONDRION
Volume 7, Issue 1-2, Pages 125-132Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2006.11.021
Keywords
Plasmodium falciparum; mitochondrion; apicoplast; fluorescence-activated organelle fractionation
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Funding
- Medical Research Council [MC_U117532072] Funding Source: Medline
- Medical Research Council [MC_U117532072] Funding Source: researchfish
- MRC [MC_U117532072] Funding Source: UKRI
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The mitochondrion and the apicoplast of the malaria parasite, Plasmodium spp. is microscopically observed in a close proximity to each other. In this study, we tested the suitability of two different separation techniques - Percoll density gradient centrifugation and fluorescence-activated organelle sorting - for improving the purity of mitochondria isolated from the crude organelle preparation of Plasmodium falciparum. To our surprise, the apicoplast was inseparable from the plasmodial mitochondrion by each method. This implies these two plasmodial organelles are bound each other. This is the first experimental evidence of a physical binding between the two organelles in Plasmodium. (c) 2006 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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