Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 12, Issue 1, Pages 71-77Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2006.10.010
Keywords
barker hypothesis; fetal programming; intrauterine growth restriction; macrosomia; maternal nutrition
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Since the original publication of the theory of the fetal origins of adult diseases more than 15 years ago, extensive epidemiological studies have linked the environment in utero to adult health. Maternal nutrition and metabolism are major mechanisms by which the intrauterine environment programs the health of the offspring. Both growth-restricted and overgrown fetuses are at risk for postnatal disease. This paper summarizes the nutritional and metabolic causes of both these conditions and also reviews the interventions that have been tested to mitigate these effects. (c) 2006 Elsevier Ltd. All rights reserved.
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