Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 40, Issue 2, Pages 141-150Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar068200o
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Funding
- NIGMS NIH HHS [R01 GM063587-06, R01 GM063587, GM 63587, R01 GM063587-05, R01 GM063587-07, R01 GM063587-07S1] Funding Source: Medline
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We describe the design, synthesis, and properties of DNA-like molecules in which the base pairs are expanded by benzo homologation. The resulting size-expanded genetic helices are called xDNA (expanded DNA) and yDNA (wide DNA). The large component bases are fluorescent, and they display high stacking affinity. When singly substituted into natural DNA, they are destabilizing because the benzo-expanded base pair size is too large for the natural helix. However, when all base pairs are expanded, xDNA and yDNA form highly stable, sequence-selective double helices. The size-expanded DNAs are candidates for components of new, functioning genetic systems. In addition, the fluorescence of expanded DNA bases makes them potentially useful in probing nucleic acids.
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