Journal
JOURNAL OF PROTEOME RESEARCH
Volume 6, Issue 2, Pages 443-458Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr0605217
Keywords
global metabolite profiling; metabotyping; metabonomics; metabolomics; spectroscopic analysis; separations; hyphenation
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To perform metabonomics investigations, it is necessary to generate comprehensive metabolite profiles for complex samples such as biofluids and tissue/tissue extracts. Analytical technologies that can be used to achieve this aim are constantly evolving, and new developments are changing the way in which such profiles' metabolite profiles can be generated. Here, the utility of various analytical techniques for global metabolite profiling, such as, e.g., H-1 NMR, MS, HPLC-MS, and GC-MS, are explored and compared.
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