Journal
ANALYTICAL CHEMISTRY
Volume 79, Issue 3, Pages 916-922Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac061246a
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Funding
- National Research Foundation of Korea [2002-203-H00032, mostR01-2002-000-00294-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Surface-enhanced Raman scattering (SERS) imaging has been used for the targeting and imaging of specific cancer markers in live cells. For this purpose, Au/Ag core-shell nanoparticles, conjugated with monoclonal antibodies, were prepared. The procedures to label live cells with those bimetallic nanoprobes have been developed and used for highly sensitive SERS imaging of live cells. In the present study, live HEK293 cells expressing PLC gamma 1 have been used as the optical imaging target. Our results demonstrate the potential feasibility of SERS imaging technology for the highly sensitive imaging of cancer biomarkers in live cells.
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